In all honesty, just the concept of giving her blood away gives Ochako the worst, kneejerk reaction and correlation to Toga, so her aversion to share even a drop of it is extremely high. She knows well the consequence of what even a little can do, and she's not exactly enthused about the fact that yes, people in this world can do things with it, far worse things than just take her shape and form. Sometimes it is necessary, but...she's also been trying to avoid it vehemently.

Seeing the reaction does make Ochako giggle a bit, but then her smile drops when Izuku seizes up. Now that she can, Ochako shifts closer to her friend and sets her utensils down completely to pull him into a very loose hug. She remembers that the reason why he ran away in the first place was because something happened - he lost a friend, blamed himself, and the corruption started and then escalated. Izuku has always been like that, but...it's not totally the right thing.

"Deku, I know it's hard. It's probably way harder here than back home, but you can't take on everything yourself. You don't have to. I know it's part of who we are as Heroes, but..." she takes a deep, steadying breath and gives his shoulders a little squeeze. "We're always going to be in danger, we're always going to be putting our lives on the line, always getting hurt - that can't be helped anymore, Deku. But we can help people together, all of us. You know that Bakugou, Todoroki, me, and everyone else is real strong, right? Trust us to get through whatever as a team, ne?"

She smiles gently at him, pulling back to pat his head. "It took all three of us students to get you back, remember?"